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The following excerpts, from Dr Boch article, will illustrate how Transfer Factor can improve allergic conditions. To read the entire article please clicks on this link.

Role of TH1, TH2

Before one can understand the usefulness of transfer factor, it is helpful to have an understanding of the TH1 helper/TH2 helper paradigm. T helper lymphocytes develop along two lines of cell populations. TH1 cells, which modulate cell-mediated immunity, produce the cytokines: IL-2, IFN-gamma, and TNF-alpha. TH2 cells, which modulate humoral immunity, or antibody production, produce IL-4, IL-5, IL-6, IL-10, and IL-13. Once you’re familiar with the particular TH1/TH2 predominant phenotypes in a patient, you can more easily identify certain constellations of diseases or conditions, and tailor your therapies.

Cell-mediated or TH1 helper responses are important in the body’s ability to defend itself against viruses, fungi, parasites, cancer, and intracellular organisms. Cell-mediated immunity can be tested by:

1.	Skin tests–delayed hypersensitivity skin testing;
2.	Response to non-specific mitogens, such as phytohemagglutinin (PHA), concavalina, or pokeweed mitogens;
3.	Response to specific mitogens, such as diptheria, tetanus, or candida;
4.	Response to alloantigens—mixed lymphocyte reaction;

5.	T-cell subsets;
6.	IL-2R;
7.	NK cell level;
8.	NK cell activity;
9.	IL1 assay; and
10.	IL2 and interferon gamma, and other cytokines.

If one has a TH2-dominated condition, with decreased cellular immunity and heightened humoral immunity, the conditions that tend to prevail are:

1.	Allergies
2.	Chronic sinusitis
3.	Atopic eczema
4.	Asthma
5.	Systemic autoimmune conditions such as lupus erythematosus and mercury-induced autoimmunity
6.	Vaccination-induced state
7.	Certain cases of autism
8.	Hyperinsulinism

9.	Pertussis vaccination
10.	Malaria
11.	Helminth infection
12.	Hepatitis C
13.	Chronic giardiasis
14.	Hypercortisolism
15.	Chronic candidiasis
16.	Cancer
17.	Viral infections
18.	Ulcerative colitis

A TH1-dominated picture would include the following medical states:

1.	Diabetes type 1
2.	Multiple sclerosis
3.	Rheumatoid arthritis
4.	Uveitis
5.	Crohn’s disease
6.	Hashimoto’s disease

7.	Sjögren’s syndrome
8.	Psoriasis
9.	Sarcoidosis
10.	Chronic Lyme disease
11.	H. pylori infections
12.	E. histolytica

Pregnancy is a TH2-dominant state. This is an advantage during pregnancy, since a TH1-dominant state, or cell-mediated immune response, would induce rejection of the fetus and placenta.(3) Because it stimulates a TH1 response in most cases, transfer factor should not be used in pregnancy. Certain autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, which are TH1-dominant states, are ameliorated during pregnancy.(4)

Transfer Factor in Gynecological Conditions
• HPV infections • Chronic vaginitis • Chronic candidiasis	• Gynecologic cancer • Genital herpes

TH1-dominant states are generally not helped by Transfer factors, and could be exacerbated. Many of them, such as rheumatoid arthritis, multiple sclerosis, and Crohn’s disease, are thought to be possibly caused by an infection or reaction to a pathogen. If the TH1 response is an inadequate attempt of the immune system to fight off a microbe, then transfer factor would augment that process and be effective in certain cases. Clinically, this is seen in certain cases, e.g., Crohn’s disease, mutiple sclerosis, and chronic Lyme disease, where transfer factor helps a TH1-dominant condition.

Transfer factor augments cell-mediated immunity or pushes a TH2 to a TH1 state. This is useful in TH2-dominated conditions. Normally, on exposure to gut-related microbes and childhood infections, a child’s TH2-dominated immune system is subject to TH1 stimulation and TH1/TH2 balance ensues.(5) If TH2 dominance remains, this can lead to atopic, or allergic states. We see this in the increased incidence of allergic symptoms, postnasal drip, asthma, etc., in clinical practice.

The other side of this TH2 state is a decreased TH1 or cell-mediated immunity. With this, we see an increased incidence of viral infection, fungal infection, and cancer. Vaccinations tend to push the immune system toward a TH2-dominant state. To help overcome this tendency, we can use transfer factor pre- and post-immunization.

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