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Causes
Starting at about age 30, testosterone levels
drop by about 10 percent every decade. At the same time, another factor in
the body called Sex Binding Hormone Globulin, or SHBG, is increasing. SHBG
traps much of the testosterone that is still circulating and makes it
unavailable to exert its effects in the body's tissues. What's left over
does the beneficial work and is known as "bioavailable" testosterone.
Andropause is associated with low
(bioavailable) testosterone levels. Every man experiences a decline of
bioavailable testosterone but some men's levels dip lower than others. And
when this happens these men can experience andropausal symptoms.
These symptoms can impact their quality of
life and may expose them to other, longer-term risks of low-testosterone. It
is estimated that 30 percent of men in their 50s will have testosterone
levels low enough to be causing symptoms or putting them at risk.

Impact of Low Testosterone
When there is less testosterone available to
do its work, the testosterone target-organ response decreases, bringing
about many changes.
There is great variability in testosterone
levels among healthy men so not all will experience the same changes to the
same extent. But typical responses to low bioavailable testosterone levels
include:
 | Low sex drive |
 | Emotional, psychological and behavioral
changes |
 | Decreased muscle mass |
 | Loss of muscle strength
|
 | Increased upper and central body fat
|
 | Osteoporosis or weak bones and back pain
|
 | Cardiovascular risk |
Why should andropause be taken
seriously?
Apart from the impact that andropause may have on your quality of
life, there are other longer-term and silent effects of andropause that are
harder to track: increased cardiovascular risk and osteoporosis.
Andropause & Osteoporosis
In a healthy individual, bone tissue is constantly being broken
down and rebuilt. In an individual with osteoporosis, more bone tissue is
lost than is regenerated. We've all heard of women suffering from weaker
bones, or osteoporosis, after menopause. In men, testosterone is thought to
play a role in helping to maintain this balance. Between the ages of 40 and
70 years, male bone density falls by up to 15 percent.
Unfortunately, with advancing age and
declining testosterone levels, men, like women, seem to demonstrate a
similar pattern of risk for osteoporosis. What's more, approximately one in
eight men over age 50 actually have osteoporosis.
The incidence of hip fractures rises
exponentially in ageing men, as it does in women, starting about 5 to 10
years later. In Canada, 20-30 percent of osteoporotic fractures occur in
men. The incidence of fractures has been increasing in men, whereas it seems
to be stabilizing in women - likely due to their lifestyle changes, calcium
supplements and hormone replacement therapies (HRT).
Low bone density puts one at risk of frequent
fractures, associated pain, and in many cases, loss of independence. Wrists,
hips, spine and ribs are most commonly affected.
Two important consequences of osteoporosis
are often seen as a slow but progressive rounding of the shoulders as well
as a loss of height and back pain. Particularly devastating seem to be hip
fractures, up to one third of patients never seem to regain full mobility.
Cardiovascular risk*
It is now well accepted that women's risk of atherosclerosis (hardening of
the arteries) increases after menopause. Estrogen replacement therapy seems
to reverse this trend.
New evidence suggests that a similar
phenomenon occurs in men as their testosterone levels diminish with age.
While research is not as complete as for women, the clinical findings point
to an association between low-testosterone levels and an increase in
cardiovascular risk factors in men.
*A cause and effect relationship has not yet
been established in large clinical trials. Further clinical research is
needed into this important area of study.
Importance of
Testosterone
Testosterone is a hormone that has a unique
effect on a man's total body. Testosterone is produced in the testes and in
the adrenal glands. It is to males what estrogen is to females.
Testosterone helps to build protein and is
essential for normal sexual behavior and producing erections. It also
affects many metabolic activities such as production of blood cells in the
bone marrow, bone formation, lipid metabolism, carbohydrate metabolism,
liver function and prostate gland growth.

Diagnosis
| Andropause is often underdiagnosed
because symptoms can be vague and can vary a lot among individuals.
Some men find it difficult to admit that there's even a problem. And
often physicians didn't always think of low-testosterone levels as a
possible culprit.
So these factors often lead doctors
to conclude that symptoms were related to other medical conditions
(i.e. depression) or were simply related to ageing and often
encouraged their patients to accept that "they were no longer spring
chickens".
But this situation is changing. New
blood testing methods are available and there is increased interest
in mens' ageing among medical researchers. In fact, so much
attention is being focused on andropause that major efforts are
underway to quickly share emerging scientific information with
physicians worldwide.
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|
Do I Have Andropause?
Andropause is a hormone-related
condition of low-testosterone. It usually occurs in males aged 40
and onwards. Take this test and find out if you have the symptoms of
andropause.
To complete the quiz, simply fill in
the answers by clicking on a "YES" or "NO" box. Once you have
finished, click "Submit" to view your results.
Here are some of the
questions, to which six positive answers, may indicate that you may
indeed have the symptoms of Andropause.
Testosterone
Replacement Therapy
In many instances, testosterone
replacement in men with andropause can be highly effective
and beneficial. It's not for every man, of course, even those who
show symptoms on the previous
quiz may have other health problems at the root of it all. Still
you should discuss with your doctor if you would be a good candidate
for testosterone replacement therapy.
What should I expect from
testosterone replacement?
In various clinical studies, very good responses to
testosterone have been reported for men with low-testosterone and
they include:
 | Improvement in mood and sense of
well-being |
 | Increased mental and physical
energy |
 | Decreased anger, irritability,
sadness, tiredness, nervousness |
 | Improved quality of sleep
|
 | Improved libido and sexual
performance |
 | An increase in lean body mass, a
decline in fat mass |
 | An increase in muscle strength
(hand grip, upper and lower extremities) |
 | Potentially, a decrease in the
risk of heart disease |
With
testosterone therapy, one's attitude improves, reinforcing
self-esteem and self-confidence at work, as well as an increased
energy at home and in social activities. Most men will feel more
vigorous, experience improved energy levels, mood,
concentration, cognition, libido, sexual performance and an
overall sense of well-being. These effects are usually noted
within 3 to 6 weeks.
Other potential benefits include
maintenance or improvement in bone density, improved body
composition, muscle mass and muscle strength, as well as improvement
in visual-spatial skills.
Lifestyle
Of course, any ongoing strategy to
reduce the symptoms and risks of andropause should incorporate
lifestyle approaches such as optimal diet, regular exercise,
stress-management and the reduction of tobacco and alcohol intake. |
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